제대혈 염증성반응증후군의 In Vitro 분석

• 영문명: In Vitro Analysis of Fetal Inflammatory Response Syndrome Using Human Umbilical Cord Blood
• 발행기관: 한국보건기초의학회
• 저자명: 김은재(Kim Eun Jae) 조은경(Cho Eun Kyung)
• 간행물 정보: 『한국보건기초의학회지』제13권 제1호, 18~24쪽, 전체 7쪽
• 주제분류: 의약학 > 면역학
• 파일형태: PDF
• 발행일자: 2020.06.30

영문 초록

Fetal inflammatory response syndrome is a multisystemic disorder, defined by elevated interleukin-6 (IL-6) in fetal plasma and associated with preterm delivery and adverse neonatal outcomes. Recent evidences indicate that the elevated concentration of matrix metalloproteinase-8 (MMP-8) is associated with fetal inflammatory response syndrome. Nuclear factor kappa B (NF-κB), has central roles in human immune response. In this study, we made in vitro model of fetal inflammatory response syndrome using lipopolysaccharide (LPS) stimulation to cord blood. The purpose of this study was to demonstrate that LPS induces a release of IL-6 and MMP-8 as well as NF-κB in cord blood. LPS stimulation increased the expression of NF-κB in a time dependent manner. MMP-8 level was significantly correlated with IL-6 level. All these results directly support that IL-6 and MMP-8 could be a useful marker for the diagnosis of fetal inflammatory response syndrome.

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키워드

Fetal inflammatory response syndrome Inhibitor of NF-κB Interleukin-6 Lipopolysaccharide Matrix metalloproteinase-8