건강한 성인에서 대사증후군 예측을 위한 호모시스테인과 고감도 C 반응성 단백의 조합

• 영문명: The Effectiveness of Using a Combination of Serum Homocysteine and High Sensitivity C-Reactive Protein for Predicting Metabolic Syndrome in Healthy Adults
• 발행기관: 한국보건기초의학회
• 저자명: 신경아(Shin, Kyung A)
• 간행물 정보: 『한국보건기초의학회지』제12권 제2호, 76~82쪽, 전체 7쪽
• 주제분류: 의약학 > 면역학
• 파일형태: PDF
• 발행일자: 2019.12.31

영문 초록

High sensitivity C-reactive protein (hs-CRP) and homocysteine (Hcy) are associated with vascular inflammatory responses and confirmed to be associated with cardiovascular disease and metabolic syndrome. However, it is still unclear whether the combination of hs-CRP and Hcy predicts the development of metabolic syndrome. This study evaluated the combination of hs-CRP and Hcy as a predictor of metabolic syndrome in healthy adults. From January 2017 to August 2019, this study was conducted on healthy adults who were over 20 years old. They underwent a general health examination at a general hospital in the Seoul metropolitan area. High hs-CRP and Hcy levels were defined as outcome values corresponding to the 75th percentile of all the subjects. The diagnosis of metabolic syndrome applied the NCEP-ATP III criteria. hs-CRP increased the risk of developing metabolic syndrome in the fourth quartile more than in the first quartile. The probability of developing metabolic syndrome in the group with only high hs-CRP levels was 2.38 for men and 3.50 for women. The incidence of metabolic syndrome with a combination of both high hs-CRP and Hcy levels was 3.42 for men and 6.55 for women. In conclusion, this study demonstrated that the combination of high levels of serum hs-CRP and Hcy can be a predicting factor for a patient’s risk of developing metabolic syndrome.

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키워드

Homocysteine hs-CRP Metabolic syndrome