Extremely Low Frequency Magnetic Field Modulates the Level of Neurotransmitters

• 영문명: Extremely Low Frequency Magnetic Field Modulates the Level of Neurotransmitters
• 발행기관: 대한생리학회-대한약리학회
• 저자명: Yoon Hee Chung, Young Joo Lee, Ho Sung Lee Su Jin Chung Cheol Hee Lim Keon Woong Oh Uy Dong Sohn Eon
• 간행물 정보: 『The Korean Journal of Physiology & Pharmacology』제19권 제1호, 15~20쪽, 전체 6쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2015.01.01

영문 초록

This study was aimed to observe that extremely low frequency magnetic field (ELF-MF) may be relevant to changes of major neurotransmitters in rat brain. After the exposure to ELF-MF (60 Hz, 2.0 mT) for 2 or 5 days, we measured the levels of biogenic amines and their metabolites, amino acid neurotransmitters and nitric oxide (NO) in the cortex, striatum, thalamus, cerebellum and hippo-campus. The exposure of ELF-MF for 2 or 5 days produced significant differences in norepinephrine and vanillyl mandelic acid in the striatum, thalamus, cerebellum and hippocampus. Significant increases in the levels of serotonin and 5-hydroxyindoleacetic acid were also observed in the striatum, thalamus or hippocampus. ELF-MF significantly increased the concentration of dopamine in the thalamus. ELF-MF tended to increase the levels of amino acid neurotransmitters such as glutamine, glycine and γ-aminobutyric acid in the striatum and thalamus, whereas it decreased the levels in the cortex, cerebellum and hippocampus. ELF-MF significantly increased NO concentration in the striatum, thalamus and hippocampus. The present study has demonstrated that exposure to ELF-MFs may evoke the changes in the levels of biogenic amines, amino acid and NO in the brain although the extent and property vary with the brain areas. However, the mechanisms remain further to be characterized.

키워드

Amino acid Biogenic amines Extremely low frequency magnetic field Neurotransmitters Nitric oxide