흰쥐에서 내측 편도체가 위산 분비와 혈장 Gastrin 농도에 미치는 영향

• 영문명: Effect of Medial Amygdala on Gastric Acid Secretion and Plasma Gastrin Concentration in Conscious Rats
• 발행기관: 대한생리학회
• 저자명: 윤신희(Yoon, Shin-Hee) 김정진(Kim, Chung-Chin) 김명석(Kim, Myung-Suk) 조양혁(Jo, Yang-Hyeok) 한상준(Hahn, Sang-June
• 간행물 정보: 『대한생리학회지』제23권 제1호, 119~128쪽, 전체 10쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 1989.06.30

영문 초록

This study was undertaken to investigate the effect of medial amygdala on the gastric acid secretion and plasma gastrin concentration in the rats with chronic gastric fistula. After the medial nucleus of amygdala was damaged bilaterally by radiofrequency a. c. through stereotaxically inserted electrodes, the gastric juice was collected in the basal and histamine-stimulated states for 1 hour. The gastric juice was also collected while the medial nucleus of amygdala was stimulated with biphasic square wave in the both states. After the collection of the gastric juice, blood samples were drawn from the abdominal aorta for the radioimmunoassay of plasma gastrin. The results were as follows: 1) The damage of the medial amygdala significantly decreased the gastric juice volume and the acid output in the histamine-stimulated state. 2) The electrical stimulation of the medial amygdala significantly increased the gastric juice volume and the acid output in the histamine-stimulated state, and the acid output in the basal state. 3) The damage of the medial amygdala significantly decreased the plasma gastrin concentration but the electrical stimulation of the medial amygdala did not affect the plasma gastrin concentration. It is therefore suggested that the medial amygdala has a facilitatory influence on the histamine-stimulated gastric acid secretion in rats, and the influence may not be attributed to gastrin release.

키워드

Medial amygdala Gastric acid secretion Gastrin Conscious rat