한국인 여성에서 UCP유전자다형성이 혈압에 미치는 영향

• 영문명: Effects of UCP Polymorphisms on Blood Pressure Among Korean Female Subjects
• 발행기관: 한방비만학회
• 저자명: 신승우(Seung Uoo Shin) 최영민(Young Min Choi) 이형철(Hyung Chul Lee) 김길수(Kil Soo Kim) 문진석(Jin Seok Moon) 차민호(
• 간행물 정보: 『대한한방비만학회지』제6권 1호, 81~92쪽, 전체 12쪽
• 주제분류: 의약학 > 한의학
• 파일형태: PDF
• 발행일자: 2006.06.30

영문 초록

Recent studies have provided some clues with regard to the relationship existing between uncoupling proteins (UCPs) and blood pressure in animal experiments. In an attempt to determine the genetic polymorphisms of UCPs that are associated with blood pressure in humans, we have analyzed genetic polymorphisms in members of the UCP family, including UCP1, UCP2 and UCP3. Methods : In this study, we assessed the association between UCP genotypes and systolic blood pressure (SBP) and diastolic blood pressure (DBP), in a population comprised of 832 Korean female subjects, using a general linear model, which was adjusted for both age and BMI. Results : Among 14 SNPs and the haplotypes constructed from them, haplotype3 of UCP1 (UCP1-ht3) evidenced significant associations with SBP (P=0.0053) and DBP (P=0.0130). However, this haplotype was not significantly associated with obesity phenotypes, including BMI or fat mass (P>0.05), thereby suggesting that its association with blood pressure was not mediated by obesity phenotypes. Conclusions : The source of variations in SBP were determined to occur in the following order: BMI (12.8 %), age (1.2 %) and UCP1-ht3 (1.1 %). Although BMI appears to exert greater effects on blood pressure, the UCP1-ht3 genotype was also found to exert a significant effect.

목차

Ⅰ. 서 론

Ⅱ. 본 론

Ⅲ. 결 과

Ⅳ. 고 찰

Ⅴ. 결 론

참고문헌

키워드

UCP SNP Association Blood Pressure SBP DBP