UCP-2, 3 단일염기다형성이 한국인 여성의 체중감량에 미치는 영향

• 영문명: The Effects of UCP-2, 3 Polymorphisms on Weight Loss among Korean Overweight Women
• 발행기관: 한방비만학회
• 저자명: 심우진(Woo Jin Shim) 문진석(Jin Seok Moon) 최선미(Sun Mi Choi) 신승우(Seung Uoo Shin) 김길수(Kil Soo Kim)
• 간행물 정보: 『대한한방비만학회지』제6권 2호, 59~73쪽, 전체 15쪽
• 주제분류: 의약학 > 한의학
• 파일형태: PDF
• 발행일자: 2006.12.31

영문 초록

This study was conducted to investigate the effects of Uncoupling protein (UCP) polymorphisms on weight loss. We analyzed associations between polymorphisms of UCP-2, 3 and changes in percentage of obesity phenotypes (Body mass index and percent body fat) after treatment. Materials and Methods: A total of 207 Korean women (BMI over 25) were recruited from the obesity clinic in Kirin Oriental Medical Hospital (Seoul, Korea). All patients were treated with a very low calorie diet and oriental medical therapy for one month. The effect of UCP polymorphisms on changes in obesity-phenotypes were analyzed. For the genotyping of a single nucleotide polymorphism (SNPs), genomic DNA from each subject was extracted from whole blood and genotyped using the TaqMan Method. Associations between changes in percentage of obesity phenotypes (BMI and percent body fat) and UCP polymorphisms were analyzed using age-adjusted general linear model. Results and Conclusions: In this study, AG, GG type of UCP-2 -866A>G, CC, CT type of UCP-2 +4787C>T, CG, GG type of UCP-3 +2564C>G, AG, GG type of UCP-3 +3106A>G, and TC, CC type of UCP-3 +4589T>C played a role as a resistance gene to weight loss.

목차

Ⅰ. 서 론

Ⅱ. 연구대상 및 방법

Ⅲ. 연구결과

Ⅳ. 고 찰

Ⅳ. 결 론

참고문헌

키워드

UCP Polymorphism Obesity Weight Loss Korean Women