방기황기탕의 유전자 다형성에 따른 비만 치료 효과: 무작위 배정, 이중 맹검, 위약-대조군 임상시험

• 영문명: Impact of GNB3, ADRB3, UCP2, and PPARγ-Pro12Ala polymorphisms on Boiogito response in obese subjects : A randomized, double-blind, placebo-controlled trial
• 발행기관: 한방비만학회
• 저자명: 박정현(Jung Hyun Park) Shambhunath Bose 임지연(Chi Yeon Lim) 김호준(Ho Jun Kim)
• 간행물 정보: 『대한한방비만학회지』제12권 2호, 28~43쪽, 전체 16쪽
• 주제분류: 의약학 > 한의학
• 파일형태: PDF
• 발행일자: 2012.12.31

영문 초록

The aim of the study was to investigate the efficacy of Boiogito for obesity. We examined the efficacy of Boiogito for obese patients and we expected the reaction of Boiogito would vary according to the single nucleotide polymorphism(SNPs). Methods 111 subjects(body mass index≥25m/kg2) were recruited and randomized to receive Boiogito(n=55) or Placebo(n=56) for 8weeks. Anthropometric factors, serum lipid profile, glucose, blood pressure(BP), pulse rate, resting metabolic rate and Korean version of obesity-related quality of life(KOQOL) scale measured at baseline and 8weeks. SNPs(β3-adrenergic receptor(ADRB3), G protein β3(GNB3), peroxisome proliferator activated receptor gamma 2 gene(PPAR-γ2), uncoupling protein(UCP2)) were conducted at baseline. Adverse reactions and safety outcome variables were also checked during trials. Results Both groups showed significant improvement on obesity after treatment. Boiogito group decreased triglyceride than did control group and improved KOQOL. Boiogito showed a significant higher efficacy in C/T and T/T genotype of GNB3 gene / in Trp64 and Arg64 genotype of ADRB3 gene / in D/D genotype of UCP2 gene / in Pro/Pro genotype of PPAR-γ gene. Conclusions Boiogito promoted obesity indexes without severe adverse reactions and proved its safety. Pharmacogenetical studies of Boiogito on obesity could be a effective method for the individualized treatment and prevention of obesity.

목차

Ⅰ. 서 론

Ⅱ. 연구 방법

Ⅲ. 연구 결과

Ⅴ. 고찰 및 결론

참고문헌

키워드

Impact of GNB3 ADRB3 UCP2 and PPARγ-Pro12Ala polymorphisms on Boiogito response in obese subjects : A randomized double-blind placebo-controlled trial