구순구개열 환자의 치아 선천결손 유형과 관련 유전자에 관한 고찰

• 영문명: Hypodontia Pattern and Genetic Association in Cleft Lip and Palate Patients
• 발행기관: 대한구순구개열학회
• 저자명: 안효원 백승학
• 간행물 정보: 『대한구순구개열학회지』제10권 제2호, 81~87쪽, 전체 7쪽
• 주제분류: 의약학 > 일반외과학
• 파일형태: PDF
• 발행일자: 2007.12.31

영문 초록

Cleft lip and palate (CLP) is one of the most prevalent congenital craniofacial anomalies. It has a significantly greater incidence of dental abnormalities in number, size, shape, and eruption of the teeth. Knout-out mouse model can identify several genes which play an important role in tooth agenesis. Since disruption of these genes has been confirmed to result in tooth agenesis in humans, CLP associated with hypodontia may be the best models for isolated tooth agenesis. According to the studies of dental abnormalities in CLP, the severity of dental defect is known to be influenced by the CLP phenotype. The cumulative data obtained from mouse and human genetic studies indicated that MSX1, PAX9 and AXIN2 are considered as candidate genes in non-syndromic hypodontia, while Shh, Pitx2, Irf6, p63 and EDA pathway genes are involved in syndromic one. We expect that genetic approach of CLP can offer the basis for tooth regeneration and be a new target in hypodontia therapy.

키워드

Cleft lip and palate Hypodontia Genetics