DOCA-Salt를 이용한 SHR의 복합질환 모델 구축

• 영문명: DOCA-Salt를 이용한 SHR의 복합질환 모델 구축
• 발행기관: 한국보건기초의학회
• 저자명: 이한기 노민희 박수경 홍용근
• 간행물 정보: 『한국보건기초의학회지』제1권 제1호, 1~6쪽, 전체 6쪽
• 주제분류: 의약학 > 면역학
• 파일형태: PDF
• 발행일자: 2008.08.14

영문 초록

There are two types of hypertension such as primary or essential hypertension (90%) and the secondary makes up the rest. Even though, many intracellular signaling molecules may contribute to the cardiac hypertrophy as primarily or secondary regulatory molecule in spontaneously hypertensive rat (SHR), it remains unknown whether establishment of complex hypertensive animal model using deoxycorticosterone acetate (DOCA) in SHR is possible or not. Thus, the present study aimed to evaluate effect of the additional induction of hypertension using DOCA-salt in SHR. Strikingly, profound raised blood pressure were revealed in DOCA-WKY rat (71.5% vs. WKY) and DOCA-SHR (63.7% vs. SHR). Interestingly, the body weight as parameter following physiological growth were significantly decreased in DOCA-WKY rats (7.3% vs. WKY) as well as DOCA-SHR (6.9% vs. SHR). These results suggest that DOCA-SHR animal model might be available for investigation of incidental mechanisms between cardiogenic hereditary hypertension and secondary metabolic hypertension.

목차

INTRODUCTION

MATERIALS & METHODS

RESULTS

DISCUSSION

REFERENCES

키워드

Animal model Deoxycorticosterone acetate (DOCA) Hypertension Wistar Kyoto (WKY) rat Spontaneously hypertension rat (SHR)