Delayed inflammation after biodegradable and osteoconductive osteofixation in orthognathic surgery

• 발행기관: 대한구강악안면외과학회
• 저자명: Young-Wook Park
• 간행물 정보: 『대한구강악안면외과학회지』제50권 제6호, 350~355쪽, 전체 6쪽
• 주제분류: 의약학 > 일반외과학
• 파일형태: PDF
• 발행일자: 2024.12.31

국문 초록

Objectives: This study aims to identify patterns and to describe the clinical course of delayed adverse tissue responses in patients who underwent orthognathic osteotomy with biodegradable osteofixation. Patients and Methods: Through a retrospective review of cases between 2013 and 2020, we identified three patients who underwent bimaxillary osteotomy and fixation with unsintered-hydroxyapatite/poly-L lactic acid (u-HA/PLLA) devices, after which they developed delayed inflammation. These lesions were treated with drainage and/or removal of the devices. Histological evaluations were conducted using H&E staining, and structural changes in the u-HA/PLLA devices were assessed by scanning electron microscopy (SEM). Results: Inflammatory lesions developed only in the mandible, with onset ranging from 12 to 35 months post-operation. Histological studies identified foreign-body granulomas or secondarily infected lesions. SEM analysis indicated biodegradation and tissue integration. Conclusion: Orthognathic patients treated using u-HA/PLLA devices should be informed about the potential for delayed inflammation and monitored for at least 3 years.

목차

I. Introduction

II. Patients and Methods

III. Results

IV. Discussion

V. Conclusion

References

키워드

Biodegradable osteofixation Delayed inflammation Foreign-body reaction