인간유두종바이러스 양성 구인두암에서 치료의 감량화

• 영문명: De-escalated Therapy for HPV Positive Oropharyngeal Cancer
• 발행기관: 대한두경부종양학회
• 저자명: 정영호(Young Ho Jung) 김정헌(Jeong Heon Kim)
• 간행물 정보: 『대한두경부종양학회지』제40권 제2호, 1~5쪽, 전체 5쪽
• 주제분류: 의약학 > 종양학
• 파일형태: PDF
• 발행일자: 2024.11.30

국문 초록

Human papillomavirus-positive (HPV+) oropharyngeal cancer has a significantly better prognosis compared to HPV-negative cases, leading to a growing interest in de-escalation strategies that reduce treatment intensity without compromising oncologic outcomes. The potential for de-escalation in the treatment of HPV+ oropharyngeal cancer extends not only to radiation therapy but also to surgical interventions. This involves reducing the extent of surgery through minimally invasive techniques and minimizing the necessity or dosage of radiation therapy by employing neoadjuvant chemotherapy prior to surgery. De-escalated surgical approaches, which include minimized surgical fields, minimally invasive procedures, and the use of neoadjuvant chemotherapy, may effectively preserve oncologic control while improving patients' quality of life. However, careful patient selection and long-term outcome data are critical for optimizing these strategies.

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De-escalation HPV-positive (HPV+) oropharyngeal cancer Minimally invasive surgery (MIS) Neoadjuvant chemotherapy (NAC) Transoral robotic surgery (TORS)