The role of endoplasmic reticulum stress in the pathogenesis of oral diseases

• 발행기관: 대한구강악안면외과학회
• 저자명: Kezia Rachellea Mustakim Mi Young Eo Soung Min Kim
• 간행물 정보: 『대한구강악안면외과학회지』제50권 제4호, 177~188쪽, 전체 12쪽
• 주제분류: 의약학 > 일반외과학
• 파일형태: PDF
• 발행일자: 2024.08.31

국문 초록

The endoplasmic reticulum (ER) is crucial for protein synthesis, transport, and folding, as well as calcium storage, lipid and steroid synthesis, and carbohydrate metabolism. Endoplasmic reticulum stress (ERS) occurs when misfolded or unfolded proteins accumulate in the ER lumen due to increased protein secretion or impaired folding. While the role of ERS in disease pathogenesis has been widely studied, most research has focused on extraoral diseases, leaving the role of ERS in intraoral diseases unclear. This review examines the role of ERS in oral diseases and oral fibrosis pathogenesis. A systematic search of literature through July 2023 was conducted in the MEDLINE database (via PubMed) using specific terms related to ERS, oral diseases, and fibrosis. The findings were summarized in both table and narrative form. Emerging evidence indicates that ERS significantly contributes to the pathogenesis of oral diseases and fibrosis. ERS-induced dysregulation of protein folding and the unfolded protein response can lead to cellular dysfunction and inflammation in oral tissues. Understanding the relationship between ERS and oral disease pathogenesis could offer new therapeutic targets for managing oral health and fibrosis-related complications.

목차

Ⅰ. Background

Ⅱ. Methods

Ⅲ. Results

Ⅳ. Discussion

Ⅴ. Conclusion

ORCID

Authors’ Contributions

Funding

Acknowledgments

Conflict of Interest

References

키워드

Endoplasmic reticulum stress Fibrosis Oral pathology Pathogenesis-related proteins Unfolded protein response