Efficacy of submucosal injection of hyaluronidase after mandibular third molar surgery: a randomized controlled trial

• 영문명: Efficacy of submucosal injection of hyaluronidase after mandibular third molar surgery: a randomized controlled trial
• 발행기관: 대한구강악안면외과학회
• 저자명: Sanghoon Lee Hyounmin Kim Woong Nam
• 간행물 정보: 『대한구강악안면외과학회지』제48권 제6호, 363~370쪽, 전체 8쪽
• 주제분류: 의약학 > 내과학
• 파일형태: PDF
• 발행일자: 2022.12.31

영문 초록

Objectives: This study aimed to investigate the efficacy of postoperative submucosal injection of hyaluronidase (HUD) for reducing sequelae and quality of life (QOL) after mandibular third molar (M3M) surgery. Materials and Methods: Participants with bilateral impacted M3M underwent surgical extraction with a split-mouth randomized controlled study design. M3M were removed by the same surgeon in 2 sessions, one a control and the other experimental. Submucosal injection of HUD was performed in the experimental session and submucosal injection of saline in the control session. Mouth opening, facial swelling, and pain intensity were measured before surgery, and then 2 and 7 days after surgery. The QOL of participants following surgery was evaluated by means of a patient-centered outcome questionnaire (PCOQ). Results: A total of 36 patients was included in the final data analysis. There was a significant reduction in the maximal mouth opening and postoperative pain in the experimental side at the 2 and 7 days after surgery (P<0.05), and a remarkable difference in facial swelling was reported on the experimental side 7 days after surgery (P<0.05). The PCOQ demonstrated that participants reported less pain and swelling on the experimental side. Conclusion: The present study provides clinical evidence that submucosal administration of HUD immediately after M3M surgery reduced postoperative discomfort and improved patients’ QOL.

목차

I. Introduction

II. Materials and Methods

III. Results

IV. Discussion

V. Conclusion

ORCID

Authors’ Contributions

Ethics Approval and Consent to Participate

Consent for Publishing Photographs

Conflict of Interest

References

키워드

Third molars Hyaluronidase Pain Edema Trismus