MicroRNA and Their Potential Role in Conjunctival Disorders

• 영문명: MicroRNA and Their Potential Role in Conjunctival Disorders
• 발행기관: 대한안과학회
• 저자명: Nazmul Huda Syed Embong Zunaina Shahidan Wan-Nazatul Shima Malvika Sharma Ismail Shatriah
• 간행물 정보: 『The Korean Journal of Ophthalmology』Vol.36 No.5, 452~462쪽, 전체 11쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2022.10.31

영문 초록

MicroRNAs (miRNAs) are the small noncoding RNA molecules which regulate target gene expression posttranscriptionally. They are known to regulate key cellular processes like inflammation, cell differentiation, cell proliferation, and cell apoptosis across various ocular diseases. Due to their easier access, recent focus has been laid on the investigation of miRNA expression and their involvement in several conjunctival diseases. The aim of this narrative review is to provide understanding of the miRNAs and describe the current role of miRNAs as the mediators of the various conjunctival diseases. A literature search was made using PubMed, Scopus, and Web of Science databases for studies involving miRNAs in the conjunctival pathological conditions. Original articles in the last 10 years involving both human and animal models were included. Literature search retrieved 27 studies matching our criteria. Pertaining to the numerous literatures, there is a strong correlation between miRNA and the various pathological conditions that occur in the conjunctiva. miRNAs are involved in various physiological processes such as cell differentiation, proliferation, apoptosis, development, and inflammation by regulating various signaling pathways, genes, proteins, and mediators. Pterygium was the most studied conjunctival disease for miRNA involvement, whereas miRNA research in allergic conjunctivitis is still in its early stages. Our review provides deep insights into the various miRNAs playing an important role in the various conjunctival diseases. miRNAs do have the potential to serve as noninvasive biomarkers with diagnostic, prognostic, and therapeutic implications. However, multitudinous studies are required to validate miRNAs as the reliable biomarkers in conjunctival pathologies and its targeted therapy.

목차

Introduction

Background

Methods for Qualification of miRNAs

miRNA Expression in the Eye Development

Role of miRNAs in the Conjunctival Disorders

Conclusion

References

키워드

Biomarkers Conjunctival diseases MicroRNAs Small untranslated RNA