Prognosis of tongue squamous cell carcinoma associated with individual surgical margin and pathological features

• 영문명: Prognosis of tongue squamous cell carcinoma associated with individual surgical margin and pathological features
• 발행기관: 대한구강악안면외과학회
• 저자명: Seongji Cho Buyanbileg Sodnom-Ish Mi Young Eo Ju Young Lee Ik Jae Kwon Hoon Myoung Hye Jung Yoon
• 간행물 정보: 『대한구강악안면외과학회지』제48권 제5호, 249~258쪽, 전체 10쪽
• 주제분류: 의약학 > 내과학
• 파일형태: PDF
• 발행일자: 2022.10.31

영문 초록

The specific muscular structure of the tongue greatly affects margin shrinkage and tumor invasion, making the optimal surgical margin controversial. This study investigated surgical margin correlated prognosis of TSCC (tongue squamous cell carcinoma) according to margin location and its value, and the histopathologic factors which are suggestive of tumor invasion. And we would like to propose defining of the surgical margin for TSCC via prognosis according to location and margin values. We reviewed 45 patients diagnosed with TSCC who visited Seoul National University Dental Hospital (SNUDH) (Seoul, Republic of Korea) from 2010 to 2019, who were managed by a single surgical team. Patient clinical and pathological data of patients were retrospectively reviewed, and in 36 out of 45 patients, the pathologic parameters including the worst pattern of invasion (WPOI) and tumor budding were investigated via diagnostic histopathology slide reading. When standardized with as 0.25 cm anterior margins, as 0.35 cm deep margin, there was no significant difference in disease specific survival (DSS) or loco-regional recurrence-free survival (LRFS). Additionally, there was a non-significant difference in DSS and LRFS at the nearest margin of 0.35 cm (PDSS=0.276, PLRFS=0.162). Aggressive WPOI and high tumor budding showed lower survival and recurrence-free survival, and there were significant differences in close margin and involved margin frequencies. In TSCC, the value and location of the surgical margin did not have a significant relationship with prognosis, but WPOI and tumor budding suggesting the pat-tern of muscle invasion affected survival and recurrence-free survival. WPOI and tumor budding should be considered when setting an optimal surgical margin.

목차

Ⅰ. Introduction

Ⅱ. Materials and Methods

Ⅲ. Results

Ⅳ. Discussion

ORCID

Authors’ Contributions

Acknowledgements

Ethics Approval and Consent to Participate

Supplementary Materials

Conflict of Interest

References

키워드

Oral tongue squamous cell carcinoma Surgical margin Worst pattern of invasion Tumor budding