Radiotherapy, volume reduction, and short-term surgical outcomes in the treatment of large myxoid liposarcomas

• 영문명: Radiotherapy, volume reduction, and short-term surgical outcomes in the treatment of large myxoid liposarcomas
• 발행기관: 대한방사선종양학회
• 저자명: Linus Hyunsuk Lee Sarah Tepper Grant Owen Dian Wang Nicolas Lopez-Hisijos Matthew W. Colman
• 간행물 정보: 『대한방사선종양학회지』제40권 제3호, 172~179쪽, 전체 8쪽
• 주제분류: 의약학 > 종양학
• 파일형태: PDF
• 발행일자: 2022.09.30

영문 초록

Purpose: While tumor volume reduction following radiation has been documented in myxoid liposarcomas, it is unclear whether large tumors experience similar volume reduction to smaller tumors. Materials and Methods: MRI studies performed before and after completion of pre-operative radiation therapy (RT) were examined. Tumor sizes were noted and categorized as large versus small based on size >10 cm. Tumor volumes were calculated, and operative duration and major wound complications were recorded. Results: The median largest tumor dimension was 12.4 cm before RT and 8.7 cm after RT. The median tumor volume was 298.9 cm3 before RT and 106.9 cm3 after RT. There was no significant difference in the mean percent tumor volume reduction between large tumors and small tumors (p = 0.11, 56.3% vs. 64.5%). Operative duration most strongly correlated to post-RT MRI volume (R2=0.674, p<0.001). Despite volume reduction, tumors that were large on presentation were more likely to experience major wound complications post-operatively. Conclusion: Radiation appears to be as effective at reducing myxoid liposarcoma tumor volume in large and small tumors. However, large tumors on presentation appear more likely to experience wound complications despite tumor volume reduction. Future studies should investigate disease-related outcomes as a factor of volume reduction in myxoid liposarcoma.

목차

Introduction

Materials and Methods

Results

Discussion and Conclusion

Statement of Ethics

Conflict of Interest

Funding

Data Availability Statement

References

키워드

Myxoid liposarcoma Soft tissue sarcoma Radiotherapy Neoadjuvant radiation