Changes in Brain Activity of Rats due to Exposure to Fine Dust Using ¹⁸F-FDG PET

• 영문명: ¹⁸F-FDG PET를 이용한 미세먼지 노출에 따른 쥐(rat)의 뇌 활성도 변화
• 발행기관: 대한방사선과학회(구 대한방사선기술학회)
• 간행물 정보: 『방사선기술과학』방사선기술과학 제45권 제3호, 225~232쪽, 전체 8쪽
• 주제분류: 의약학 > 방사선과학
• 파일형태: PDF
• 발행일자: 2022.06.30

영문 초록

Fine dust threatens human health in various forms, depending on the particle size, such as by causing respiratory, cardiovascular, and brain diseases, after entering the body via the lungs. The aim of this study was to correlate fine dust exposure with changes in brain blood flow in Sprague Dawley rats by using micro-positron emission tomography and elucidate the possibility of developing cerebrovascular diseases caused by fine dust. The subjects were exposured to an average fine dust (particulate matter 2.5) of 206.2 ± 7.74 to ten rats four times a day, twice a day for 90 min. Before the experiment, they were maintained at NPO to the maximize the intake of 18F-fluorodeoxy glucose(18F-FDG) and minimize changes in the 18F-FDG biomass depending on the ambient environment and body temperature of the rats. PET images were acquired in the list mode 40 min after injecting 18F-FDG 44.4 MBq into the rats tail vein using a micro-PET scanner pre and post exposure to fine dust. We found that the whole brain level of 18F-FDG standardized uptake value in rats averaged 5.21 ± 0.52 g/mL pre and 4.22 ± 0.48 g/mL post exposure to fine dust, resulting in a statistically significant difference. Fine dust was able to alter brain activity after entering the body via the lungs in various forms depending on the particle size.

목차

Ⅰ. Introduction

Ⅱ. Material and Methods

Ⅲ. Results

Ⅳ. Discussion

Ⅴ. Conclusions

키워드

표준섭취계수(SUV) Micro PET 스케너 쥐 18F-fluorodeoxy glucose 노출조건 Dust Standard uptake value (SUV) Micro-PET scanner Rats 18F-fluorodeoxy glucose(18F-FDG) Exposure conditions