내시경을 이용한 경접형동 접근 수술 중에 시행한 비강내 세균 배양 검사 및 그에 대한 항생제 감수성 결과 분석과 3세대 세팔로스포린의 예방적 항생제로서의 임상적 효과에 대한 분석

• 영문명: Analysis of intraoperative nasal cavity culture with the antibiotics susceptibility test and clinical outcomes of antibiotic prophylaxis with third-generation cephalosporins for endoscopic transsphenoidal surgery
• 발행기관: 대한두개저학회
• 저자명: 이민기(Min-Gi Lee) 박재성(Jae-Sung Park) 김도현(Do Hyun Kim) 김성원(Sung Won Kim) 전신수(Sin Soo Jeun) 홍용길(Yong-Kil Hong)
• 간행물 정보: 『대한두개저학회지』제13권 제2호, 18~27쪽, 전체 10쪽
• 주제분류: 의약학 > 일반외과학
• 파일형태: PDF
• 발행일자: 2018.09.30

영문 초록

Background : We analyzed the distribution of identified micro-organisms from the nasal cavity during EETS and their antibiotic susceptibility testing (AST) results. In addition, we evaluated the clinical outcomes of antibiotic prophylaxis with third-generation cephalosporins for endoscopic transsphenoidal surgery. Methods : From November 2014 to October 2017, a total of 225 EETS cases with available nasal cavity culture results were reviewed to identify the clinical data relevant to CNS infection. Ceftriaxone was used for antibiotic prophylaxis, and the patients were divided into subgroups according to the AST results. Results : Gram-positive cocci were the most commonly identified micro-organisms. The patient population was divided into the following three groups: prophylaxis-appropriate, prophylaxis-inappropriate, and Undetermined group, each amounting to 132 (59.5%), 34 (15.3%), and 56 (25.2%) cases, respectively. CNS infection was observed in 2 (0.9%) cases. But, statistical analyses did not show significant differences in the occurrence of CNS infection among the studied groups. Conclusions : Antibiotic prophylaxis with third-generation cephalosporins showed that most (85%) patients received appropriate prophylaxis, and the clinical outcomes regarding the CNS infection were also comparable to other previous reports. Future larger-scale studies are mandatory to establish the relationship between prophylaxis-appropriateness and the occurrence of CNS infection.

목차

INTRODUCTION

METHODS

RESULTS

DISCUSSION

CONCLUSION

키워드

Endoscopy Antibiotic prophylaxis Nasal cavity Ceftriaxone