검정콩 안토시아닌의 항산화 및 암세포독성

• 영문명: Antioxidant Activity and Cytotoxicity on Human Cancer Cells of Anthocyanin Extracted from Black Soybean
• 발행기관: 한국작물학회
• 저자명: 김용호(Yong-Ho Kim) 김동선(Dong-Seon Kim) 우성식(Sung-Sick Woo) 김현희(Hyun-Hee Kim) 이영상(Young-Sang Lee) 김희선(Hee-Seon Kim) 고광오(Kwang-Oh Ko) 이석기(Seuk-Ki Lee)
• 간행물 정보: 『한국작물학회지』제53권 제4호, 407~412쪽, 전체 6쪽
• 주제분류: 농수해양 > 기타농수해양
• 파일형태: PDF
• 발행일자: 2008.12.30

영문 초록

Anthocyanin pigments in soybean seed coat were D3G (Delphinidin-3-glucoside), C3G (Cyanidin-3- glucoside) and Pt3G (Petunidin-3-glucoside), which have been known potential roles in the prevention and treatment of chronic diseases. Anthocyanin contents in seed coat of blck soybean were significantly different according to soy-bean variety, C3G content showed the highest value in all materials and its variation was also wide. Antioxidant acti-vity of each pigment was analyzed by DPPH and TEAC methods in which D3G and C3G showed high activity. And this study was carried out to investigate the effects of anthocyanin to human cancer cells. Cytotoxity were analyzed by MTT assay after anthocyanin pigments treated on leukemia (Jurkat T) and adenocarsinoma (MCF-7) cells. It showed decrement of cell numbers as anthocyanin concentration is increasing. EC50 range of anthocyanin concentrations were 100~250 ug/mL and 100~250 ug/mL in Jurkat T and MCF-7 cell, respectively. D3G showed higher cytotoxicity than other pigments in Jurkat T cell whereas activity of C3G was high in MCF-7 cell. It is believed that supplementation of human diets with soybean anthocyanin markedly reduces human cancer mortality rates.

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soybean anthocyanin antioxidant activity cytotoxity cancer