두경부암의 최신 표적치료

• 영문명: What s New in Molecular Targeted Therapies for Head and Neck Cancer?
• 발행기관: 대한두경부종양학회
• 저자명: 이서영(Seoyoung Lee) 김혜련(Hye Ryun Kim)
• 간행물 정보: 『대한두경부종양학회지』제37권 제2호, 11~17쪽, 전체 7쪽
• 주제분류: 의약학 > 종양학
• 파일형태: PDF
• 발행일자: 2021.11.30

영문 초록

Head and neck cancer is the 6th most frequently diagnosed solid tumor in the world. Alcohol consumption, smoking, and HPV infection are associated with the incidence of head and neck squamous cell carcinoma (HNSCC). Although a multidisciplinary approach is a key strategy for the treatment of locally advanced HNSCC, systemic therapy is the mainstream of recurrent or metastatic HNSCC treatment. Stage IV HNSCC has a relatively poor prognosis with median overall survival of around one year. There have been many clinical trials to investigate the efficacy of target agents in the treatment of HNSCC. In the HPV-negative HNSCC, TP53 and CDKN2A are the most commonly mutated genes. In the HPV-positive HNSCC, the PI3K pathway is frequently altered. EGFR, PI3K, cell cycle pathway, MET, HRAS, and IL6/JAK/STAT pathway are explored targets in HNSCC. In this study, we review the target pathways and agents under research. We also introduce here umbrella trials of recurrent or metastatic HNSCC conducted by the Korea Cancer Study Group. The combination of target agents with immune checkpoint inhibitors or cytotoxic chemotherapies would be a future step in the precision medicine of HNSCC treatment.

목차

Introduction

Key pathway and genomic alteration in HNSCC

EGFR and HER/ErbB family

PI3K-AKT-mTOR 경로

Cell cycle regulators

이외 다른 표적들

Biomarker driven trial

Conclusion

References

키워드

Head and neck squamous cell carcinoma Targeted therapy Molecular pathway