Corneal Nerves Alteration Associated with Corneal Complications after Pars Plana Vitrectomy

• 발행기관: 대한안과학회
• 저자명: Tiezhu Lin Hong Ye Emmanuel Eric Pazo Guangzheng Dai Yang Xia Wei He
• 간행물 정보: 『The Korean Journal of Ophthalmology』Vol.35 No.4, 255~260쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2021.08.30

영문 초록

Purpose: To evaluate the effect of corneal nerves assessment on predicting corneal complications following pars plana vitrectomy (PPV). Methods: In this prospective single-center cohort study, 94 patients (94 eyes) received PPV, and were divided into postoperative groups with and without corneal complications. All eyes had corneal nerve fiber length (CNFL), corneal nerve fiber density, and branch density of corneal nerve fibers assessed and calculated with Image J preoperatively. Multivariate logistic regression analysis was used to identify corneal nerve fiber parameters that correlated to post-operative corneal complications. Receiver operator characteristic curve analysis was performed to identify the optimal cut-off point of the corneal fibers’ parameters for predicting corneal complications after PPV. Results: Eleven eyes (11.70%) developed corneal complications at 1 week after PPV. There was significant difference between CNFL (19.44 ± 6.88 vs. 26.84 ± 7.53, p = 0.003), corneal nerve fiber density (28.82 ± 9.91 vs. 37.10 ± 10.16, p = 0.013) and branch density of corneal nerve fibers (55.84 ± 21.08 vs. 82.04 ± 31.89, p = 0.01) in two groups, respectively. Receiver operator characteristic analysis showed that the optimal cutoff value of CNFL to predict corneal complications following PPV was <26.495 mm/mm2. Conclusions: The decrease of CNFL may predict corneal complications following PPV. Regular preoperative corneal confocal microscopy test in PPV patients could be considered.

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Conflict of Interest

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키워드

Microscope Nerve fibers Postoperative complications Vitrectomy