학술논문
The Ameliorative Effect of Rubi Fructus on DSS-induced Colitis in Mice
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- 영문명
- 발행기관
- 한국자원식물학회
- 저자명
- 명노일(Noh-Yil Myung)
- 간행물 정보
- 『한국자원식물학회지』제34권 제3호, 216~222쪽, 전체 7쪽
- 주제분류
- 농수해양 > 기타농수해양
- 파일형태
- 발행일자
- 2021.06.30
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국문 초록
영문 초록
Ulcerative colitis (UC) is an inflammatory bowel disease and a chronic gastrointestinal disorder. Rubi Fructus (RF), the fruit of Rubus coreanus Miquel, is known to exert several pharmacological effects including anti-oxidative, anti-obesity and anti-inflammatory properties. However, the improving effect and mechanism of RF on intestinal inflammation is not been fully understood. The purpose of this study was to investigate the regulatory effect of RF on dextran sulfate sodium (DSS)-induced colitis in mice. We evaluated the effects of RF on DSS-induced clinical signs by analyzing weight loss and colon length. The inhibitory effects of RF on inflammatory mediators such as prostaglandin E2 (PGE2), cyclooxygenase (COX)-2, as well as the activation of nuclear factor-κB (NF-κB), were determined in colitis tissue. Our data indicated that mice treated with DSS showed clinical symptoms of colitis, including weight loss, colon length decrease and diarrhea. However, we observed that RF treatment significantly improved these clinical symptoms of weight loss, colon length decrease and diarrhea induced by DSS. RF inhibited the enhanced levels of COX-2 and PGE2 caused by DSS. We also showed that the anti-inflammatory mechanism of RF by suppressing the activation of NF-kB in DSS-treated colon tissues. Collectively, the findings of this study indicate the prospect of developing new drugs from RF for UC treatment.
목차
Introduction
Materials and Methods
Results
Discussion
Acknowledgements
Conflicts of Interest
References
해당간행물 수록 논문
- The Report on the Taxonomic Characters, Ecological Risk and Weed Risk Assessment of Putative Invasive Alien Plants which are Designated in Law by the Ministry of Environment in Korea as Environmentally Harmful Species (III)
- In vitro Immunostimulatory Activity of Bok Choy (Brassica campestris var. chinensis) Sprouts in RAW264.7 Macrophage Cells
- The Ameliorative Effect of Rubi Fructus on DSS-induced Colitis in Mice
- Rosa laevigata Michx. (Rosaceae): A Newly Alien Plant in Korea
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