일부공단지역에 거주하는 성인남성의 알레르기 반응과 산화손상에 대한 연구

• 영문명: The relationship between allergic responses and oxidative stress among male adults in an industrial area
• 발행기관: 한국환경보건학회
• 저자명: 기영선 민진영 유홍식 백도명
• 간행물 정보: 『1. 한국환경보건학회지』제34권 제2호, 117~123쪽, 전체 7쪽
• 주제분류: 공학 > 환경공학
• 파일형태: PDF
• 발행일자: 2008.04.30

영문 초록

Allergic diseases have been dramatically increased over recent years, especially in industrialized countries. Oxidative stress has been believed to play a significant role in the occurrence of the allergic inflammatory responses. Although previous studies concerning oxidative stress and systemic inflammation have been reported, few data is available, and other allergic diseases, except for asthma, are hardly studied about the association with oxidative stress. This study evaluated the relationship between allergic disease and Malondialdehyde (MDA) as an indicator of oxidative stress. The study population was 197 male adults living in an industrial area. The ISAAC questionnaire was used to confirm wheezing and rhinitis, and atopy was evaluated by skin prick test. MDA was analyzed by spectrophotometer. To examine bronchial hyperresponsiveness (BHR), methacholine test was performed, and the index of bronchial responsiveness (BR index) was calculated. We used multivariate logistic regression model and general linear model with SAS program. We found significant associations of MDA with brindex (p=0.023), rhinitis (p=0.016), atopy (p=0.03), adjusted by age, smoking, and body mass index (BMI). On the contrary, there was no significant difference of MDA with the status of asthma. Our result suggests that oxidative stress may play a major role in the occurrence of allergic response in male adults.

키워드

oxidative stress bronchial hyperresponsiveness rhinitis skin prick test