미성숙 랫드 자궁비대반응시험을 이용한 DEHA의 내분비계 장애작용 평가

• 영문명: Immatured Type Uterotrophic Assay for Estrogenicity Evaluation of DEHA
• 발행기관: 한국환경보건학회
• 저자명: Park, Ki-Dae Han, Beom-Seok Jeong, Ja-Young Oh, Jae-Ho Cho, Wan-Seob Cho, Min-Jeong Choi, Mi-Na Kim, Sung-Joon Kim, Seung-Hee
• 간행물 정보: 『1. 한국환경보건학회지』제33권 제5호, 379~385쪽, 전체 7쪽
• 주제분류: 공학 > 환경공학
• 파일형태: PDF
• 발행일자: 2007.10.30

영문 초록

This study was aimed to investigate the estrogenic activity of Di-(2-ethylhexyl) adipate (DEHA) using immatured type uterotrophic assay. SD rats were treated with DEHA (40, 200, 1000 mg/kg/day), estradiol-3-benzoate (EB) (1mg/kg/day) as positive control on the assay. In immatured-type uterotrophic assay, relative organ weights of kidney and reproductive organs such as ovary at high-dose group were significantly increased compared to those of vehicle control group. DEHA did not influence the levels of serum FSH and LH, and uterine morphological changes such as luminal epithelial height, myometrial thickness and numbers of uterine gland, and BrdU indices. In these results, there was no significant variation by DEHA treatment, suggesting that DEHA appears not to be a endocrine disrupter with estrogenic activity.

키워드

DEHA immatured type uterotrophic assay estrogenic activity