두경부암의 양성자치료

• 영문명: Proton Therapy for Head and Neck Cancer: Current Clinical Applications and Future Direction
• 발행기관: 대한두경부종양학회
• 저자명: 오동렬(Dongryul Oh)
• 간행물 정보: 『대한두경부종양학회지』제37권 제1호, 1~10쪽, 전체 10쪽
• 주제분류: 의약학 > 종양학
• 파일형태: PDF
• 발행일자: 2021.05.30

영문 초록

Intensity-modulated radiation therapy (IMRT) using X-rays is a standard technique implemented for treating head and n eck cancer (HNC). Compared to 3D conformal RT, IMRT can significantly reduce the radiation dose to surrounding normal tissues by using a highly conformal dose to the tumor. Proton therapy is a type of RT that uses positively charged particles named protons. Proton therapy has a unique energy deposit (i.e., Bragg peak) and greater biological effectiveness than that of therapy using X-rays. These inherent properties of proton therapy make the technique advantageous for HNC treatment. Recently, advanced techniques such as intensity-modulated proton therapy have further decreased the dose to normal organs with a higher conformal dose to the tumor. The usage of proton therapy for HNC is becoming widespread as the number of operational proton therapy centers has increased worldwide. This paper aims to present the current clinical evidence of proton therapy utility to HNC clinicians through a literature review. It also discusses the challenges associated with proton therapy and prospective development of the technique.

목차

Introduction

Physical and biological properties of proton therapy: the Bragg peak and RBE 1.1

What is IMPT?

Clinical evidence of proton therapy in HNC

Pitfalls of proton therapy for HNC

Future directions

Conclusion

References

키워드

Proton therapy Intensity-modulated proton therapy Radiation therapy Head and neck cancer