고련피 추출물의 항암활성

• 영문명: Anti-cancer Activities of Extract from the Bark of Melia azedarach L. var. japonica Makino
• 발행기관: 한국자원식물학회
• 저자명: 김현우(Hyun Woo Kim) 강세찬(Se Chan Kang)
• 간행물 정보: 『한국자원식물학회지』제22권 제4호, 312~316쪽, 전체 5쪽
• 주제분류: 농수해양 > 기타농수해양
• 파일형태: PDF
• 발행일자: 2009.08.31

영문 초록

In the present study, the anti-cancer activity of 80% ethanol extracts from 120 kinds of medicinal herbs and native plants were investigated. Among them, the barks of Melia azedarach L. var. japonica Makino showed the highest cytotoxicity in HCT-15 human colon cancer cell. With this result, we carried out hollow fiber (HF) assay and anti-metastasis study to confirm the anti-cancer effects of M. azedarach var. japonica. In MTT assay, M. azedarach var. japonica.inhibited the proliferation of HCT-15 cells in dose-dependent manner. HF assay was carried out using A549 human adenocarcinoma cell, HCT-15 and SK-Hep1 human liver cancer cell via intrapetoneal (IP) and subcutaneous (SC) site. As a results, SK-Hep1 implanted in IP site showed the highest cytotoxicity. The result from metastatic model using B16/BL6 mouse corresponded to that of HF assay. These results suggest that the ethanol extract from M. azedarach var. japonica. might have a potent anti-cancer activity and advanced study is needed for the development of novel natural anti-cancer drug.

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Anti-cancer human cancer cell HF assay metastasis Melia azedarach L. var. japonica Makino