생쥐의 하악 치아 절단으로 인한 부정교합이 뇌경색에 미치는 영향

• 영문명: Effect of Tooth-Cut Induced Dental Malocclusion on Mouse Model of Ischemic Stroke
• 발행기관: 턱관절균형의학회
• 저자명: 이영준(Young-Jun Lee) 이병호(Byoungho Lee) 조수인(Suin Cho)
• 간행물 정보: 『턱관절균형의학회지』제9권 제1호, 4~11쪽, 전체 8쪽
• 주제분류: 의약학 > 한의학
• 파일형태: PDF
• 발행일자: 2019.12.30

영문 초록

Objectives: Although intraoral balancing appliance therapy has been used effective to several diseases, verification studies through cerebral diseases are poorly reported so far. Thus we investigated the effect of tooth-cut induced dental malocclusion against mouse model of ischemic stroke. Methods: Tooth-cut and 90 min middle cerebral artery occlusion (MCAO) were loaded to C57BL/6 male mice, and total infarct area, neurological deficit scores (NDS), histological change of hippocampal region were observed. Production levels of reactive oxygen species (ROS) and inducible nitric oxide synthase (iNOS) in cerebral tissue were also measured. Results: The longer the tooth-cut period, the greater the area of cerebral infarction caused by MCAO, and NDS began to increase as the tooth was cut, and the results were more negative when MCAO was loaded. Histological change of hippocampal cells was significant when tooth-cut was maintained for 7 days. Those damages were thought to depend on the generation of ROS and iNOS in brain tissue. Conclusions: Since tooth-cut increased total area of cerebral infarction due to MCAO in mice, it is able to be confirmed that anomaly of the temporomandibular occlusion can affect neurological diseases.

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키워드

Intraoral balancing appliance Middle cerebral artery occlusion Mouse Stroke