Inhibition of Adenovirus 36 Replication and Lipid Accumulation by Distylium racemosum

• 영문명: Inhibition of Adenovirus 36 Replication and Lipid Accumulation by Distylium racemosum
• 발행기관: 한국응용과학기술학회 (구.한국유화학회)
• 저자명: Hye-Ran Kim Gyu-Nam Park Bo-Kyoung Jung Weon-Jong Yoon Kyung-Soo Chang
• 간행물 정보: 『한국응용과학기술학회지』한국유화학회지 제35권 제2호, 492~501쪽, 전체 10쪽
• 주제분류: 공학 > 화학공학
• 파일형태: PDF
• 발행일자: 2018.06.30

영문 초록

Obesity is a worldwide disease and one of the major risk factors. Virus among many factors can lead to obesity. Adenovirus 36 (Ad-36) is the adipogenic virus linked with human obesity. Nevertheless, there is no drug to treat both Ad-36 infection and obesity associated with virus. For the precedent study on anti-cholesterol test, Distylium racemosum (D. racemosum), Quercus salicina (Q. salicina) and Raphiolepis indica (R. indica) were selected. This study was carried out to evaluate the anti-cholesterol effects, anti-lipid effects and inhibition of Ad-36 replication from three extracts. D. racemosum (50 µg/mL) inhibited lipid accumulation on 3T3-L1 adipocyte. D. racemosum inhibited adipocyte differentiation through suppression of regulator peroxisome proliferator-activated receptorγ (PPARγ) genes and adipocyte-specific genes such as adipocyte protein 2 (aP2). D. racemosum inhibited replication of Ad-36 at 50 µg/mL of concentration. Therefore, the extract of D. racemosum could be a candidate for development of anti-Ad-36 and anti-obesity drugs.

목차

1. Introduction

2. Materials and Methods

3. Results and Discussion

4. Conclusion

키워드

Distylium racemosum, Adenovirus 36, Anti-lipid, Anti-cholesterol, Anti-obesity