학술논문
Applied mediation analyses:
이용수 19
- 영문명
- 발행기관
- 한국역학회
- 저자명
- Theis Lange Kim Wadt Hansen Rikke Sørensen Søren Galatius
- 간행물 정보
- 『Epidemiology and Health』39, 1~13쪽, 전체 13쪽
- 주제분류
- 의약학 > 면역학
- 파일형태
- 발행일자
- 2017.02.28
4,360원
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이 학술논문 정보는 (주)교보문고와 각 발행기관 사이에 저작물 이용 계약이 체결된 것으로, 교보문고를 통해 제공되고 있습니다.
국문 초록
영문 초록
In recent years, mediation analysis has emerged as a powerful tool to disentangle causal pathways from an exposure/treatment to clinically relevant outcomes. Mediation analysis has been applied in scientific fields as diverse as labour market relations and randomized clinical trials of heart disease treatments. In parallel to these applications, the underlying mathematical theory and computer tools have been refined. This combined review and tutorial will introduce the reader to modern mediation analysis including: the mathematical framework; required assumptions; and software implementation in the R package medflex. All results are illustrated using a recent study on the causal pathways stemming from the early invasive treatment of acute coronary syndrome, for which the rich Danish population registers allow us to follow patients’ medication use and more after being discharged from hospital.
목차
INTRODUCTION
SECTION 1: AN ILLUSTRATIVE CASE
SECTION 2: THE MATHEMATICAL FRAMEWORK FOR MEDIATION ANALYSIS
SECTION 3: ESTIMATING NATURAL EFFECTS MODELS
SECTION 4: ANALYSING THE ILLUSTRATIVE CASE
SECTION 5: NEW CHALLENGES WITHIN MEDIATION ANALYSIS
CONCLUSION
키워드
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