새로운 Aminoisoquinolinylamide 유도체의 합성 및 흑색종 저해 효능

• 영문명: Synthesis and Melanoma Inhibitory Activity of New Aminoisoquinolinylamide Derivatives
• 발행기관: 한국응용과학기술학회 (구.한국유화학회)
• 저자명: 조혜정(Hye Jung Cho) 유경호(Kyung Ho Yoo)
• 간행물 정보: 『한국응용과학기술학회지』한국유화학회지 제26권 제2호, 161~170쪽, 전체 10쪽
• 주제분류: 공학 > 화학공학
• 파일형태: PDF
• 발행일자: 2008.06.30

영문 초록

In this work, a novel series of aminoisoquinolinylamide derivatives 1a-c and 2a-f were synthesized via several reaction steps, starting from 2-methyl-4-nitrobenzonitrile (3) and 1-chloro-5-nitroquinoline (8). And their antiproliferative activities were screened against A375 human melanoma cell line compared to Sorafenib as a reference compound. Among them, compound 1b and 1c exhibited meaningful inhibitory activities. These results demonstrated that aminoisoquinolinylamide scaffold possesses the possibility as the treatment for melanoma.

목차

Abstract

1. 서론

2. 실험

3. 결과 및 고찰

4. 결론

감사의 글

참고문헌

키워드

aminoisoquinolinylamides synthesis antiproliferative activity melanoma cell line