고지방식이 유도된 흰쥐의 혈액지질 및 간에 관한 파리유충 추출물의 효과

• 영문명: Effects of Fly Maggot Extracts on the Liver and Plasma Lipid in Rat Fed High-Fat Diets
• 발행기관: 한국응용과학기술학회 (구.한국유화학회)
• 저자명: 박병성(Park Byung Sung)
• 간행물 정보: 『한국응용과학기술학회지』한국유화학회지 제27권 제3호, 290~299쪽, 전체 10쪽
• 주제분류: 공학 > 화학공학
• 파일형태: PDF
• 발행일자: 2009.09.30

영문 초록

The bioactive effects of ethanol extracts from fly maggot (ME) on reduction of plasma lipids levels in rats fed high-fat diets (Expt. Ⅰ), and on liver function recovery of hepatotoxicity rats by intraperitoneal injection of carbon tetrachloride (CCl4) or by orally administration of alcohol (Expt. Ⅱ) were investigated. In expt. Ⅰ, twenty seven, male rat SDS(sprague dawley strain) were randomly assigned to three treated groups, including normal control group, HF (group with high fat diets which have no extracts) and HFE (HF plus orally administered doses of ME extract at 5.0 mg/100g of body weight). In expt. Ⅱ, forty five, male rats (SDS) were randomly assigned to each of the five groups: T1 (control), T2 (intraperitoneal injection of CCl4), T3 (intraperitoneal injection of CCl4 after orally administered with ME), T4 (orally administered with combination of ME and alcohol), T5 (orally administration of ME after orally administered with alcohol). There were significant decreases in plasma (TAG), (TC), (LDL-C) in the HFE group with orally administered doses of ME at 5.0 mg/100g of body weight, respectively, however, the (HDL-C) were significantly increased in HFE group as compared to HF group with high fat diets which have no extracts (p<0.05). The levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), γ-glutamyl transferse(γ-GTP) and bilirubin were highest in T2 or T3, and high in order T4 or T5, and lowest in T1 except for bilirubin which has same with T4, T5 (p<0.05). The high recovery of liver damage by CCl4 from the light microscopic appearance was observed in rats (T3) with extracts, and also high in T4 than T5 by orally administrated with alcohol. In conclusion, the ethanol extracts from fly maggot may have a bioactive effects to prevent for human lipids disorder and alcoholic disease.

목차

1. 서 론

2. 실 험

3. 결과 및 고찰

4. 결 론

감사의 글

참고문헌

키워드

fly maggot ethanol extracts lipid profile liver protection rats