Hairless Mouse와 Pig Skin을 활용한 약물 투과성 비교

• 영문명: Comparison of Drug Delivery using Hairless Mouse and Pig Skin
• 발행기관: 한국응용과학기술학회 (구.한국유화학회)
• 저자명: 조완구(Cho WanGoo)
• 간행물 정보: 『한국응용과학기술학회지』한국유화학회지 제24권 제4호, 410~415쪽, 전체 6쪽
• 주제분류: 공학 > 화학공학
• 파일형태: PDF
• 발행일자: 2007.12.31

영문 초록

Functional cosmetics are intensively investigated for the effectiveness of skin whitening, anti-aging and slimming. For enhancing the effectiveness, active ingredients should be delivered into the cell in the dermis. The amounts of penetration of caffeine and Arbutin^{(R)} were tested, in vitro, using Franz diffusion cell. Oil-in-water emulsions were used for the vehicles of the transport. For the measuring the amounts of active ingredients delivered into the dermal skin, tape stripping was done after finishing the penetration experiments. The amounts of delivered caffeine were 8.45 + - 1.26ug/ml before tape stripping and 3.45 + - 1.80ug/ml after tape stripping, however, the amounts of delivered Arbutin^{(R)} was quite small to detect. From now on, proper vehicles are considered for enhancing the delivery of Arbutin^{(R)} Hairless mouse skin was compared with pig skin as a transdermal delivery membrane. The aspects of delivery were similar, but the amount of delivered ingredients using pig skin was larger than that of using hairless mouse skin. Therefore, the pig skin would be considered as a membrane for drug delivery experiments.

키워드

skin delivery emulsion Arbutin^{(R)} caffeine hairless mouse pig skin