Analytical Characterization of Aza-Indole Alkaloids in the Biosynthesis of Catharanthus Roseus

• 발행기관: 한국응용과학기술학회 (구.한국유화학회)
• 저자명: Hyang-Yeol Lee
• 간행물 정보: 『한국응용과학기술학회지』한국유화학회지 제29권 제2호, 248~256쪽, 전체 9쪽
• 주제분류: 공학 > 화학공학
• 파일형태: PDF
• 발행일자: 2012.06.30

영문 초록

Aza-indoles are important pharmacophores that have similar size and biological properties of indole. Here we have synthesized 4- and 7-azaindole tryptamines and showed that they are successfully incorporated in the biosynthesis of monoterepene indole alkaloids (MIAs) to form novel azaindole alkaloids by enzymatic reactions of strictosidine synthase(STR) and strictosidine glucosidase(SDG) monitored by UPLC/MS. By using HPLC equipped with a HPLC photo diode array(PDA) detector, each of the UV spectra of azaindole alkaloids was obtained and characterized. When hydrophilicity of azaindole alkaloids was compared, 4-azaindole alkaloids were more hydrophilic than 7-azaindole alkaloids

목차

1. Introduction

2. Materials and Method

3. Results and Discussion

4. Conclusions

References

키워드

Catharanthus roseus Pictet-Spengler reaction azaindole alkaloids b-carbolines deglucosylated azaindole strictosidine