Oxadiazole유도체의 고리화 첨가반응에 의한 Pyrazole유도체의 합성

• 영문명: Synthesis of Pyrazole derivatives via cycloaddition of 3-phenyloxadiazole derivatives with dipolarophiles
• 발행기관: 한국응용과학기술학회 (구.한국유화학회)
• 저자명: 이기창 황성규 이광일 최봉종
• 간행물 정보: 『한국응용과학기술학회지』한국유화학회지 제14권 제1호, 95~102쪽, 전체 8쪽
• 주제분류: 공학 > 화학공학
• 파일형태: PDF
• 발행일자: 1997.05.30

영문 초록

The synthetic method of pyrazole was performed by 1,3-dipolar cycloaddition with dipolarophile instead of the reaction between diazomethane and acetylene. The cycloaddition mechanism and reactivity of 3-phenyloxadiazole derivatives with dipolarophiles was investigated. In order to investigate the mechanism and reactivity of this cycloaddition, the effect of substituents having various kinds of electron withdrawing or releasing groups were examinated. Considering the effect of substituents, an electron withdrawing group attached at the 4-carbon position in 3-phenyloxadiazole derivatives decrease the reaction rate because of the lack of electron density in oxadiazole ring. The reaction rate of 3-phenyloxadiazole derivatives with dipolarophiles were more conveniently measured using UV than using a volumetric analysis which was used before. From the result of this study, it was that the cycloaddition was found to be a first-order reaction depending upon the concentration of 3-phenyloxadiazole only.