Gum류의 연고제제와 흡수촉진제가 Riboflavin의 경피흡수에 미치는 영향

• 영문명: Concentration of Air Pollutants and Asthma in Taejon City
• 발행기관: 한국환경보건학회
• 저자명: 서원호 장성실 권호장
• 간행물 정보: 『1. 한국환경보건학회지』제26권 제2호, 91~96쪽, 전체 6쪽
• 주제분류: 공학 > 환경공학
• 파일형태: PDF
• 발행일자: 2000.06.30

영문 초록

We investigated characters of transdermal therapeutic system(TTS) and the skin permeability of that with applying drug delivery system(DDS). Natural gums were selected as material of TTS. The permeation of natural gums ointment containing drug in rat skin using diffusion cell model. Permeation properties of materials were investigated for water soluble drug such as riboflavin in vitro. We used glycerin, PEG 600 and oleic acid as enhancers. Since dermis has more hydration than the stratum corneum, skin permeation rate at steady state was highly influenced when glycerin was used in riboflavin. The permeation rate of content enhancer and drug was found to be faster than that of content riboflavin only. These results showed that skin permeation rate of drug across the composite was mainly dependent on the property of ointment base and drug. All the gum ointment tested showed good safety. Proper selection of the materials which resemble and enhance properties of the delivering drug was found to be important in controlling the skin permeation rate.

키워드

Karaya Gum Xanthan Gum Permeation Ointment Base Enhancer