구강 편평세포암종, 백반증 및 유두종에서 Human Papillomavirus(HPV) 유형 16/18의 분포에 관한 면역조직화학적 연구

• 영문명: Immunohistochemical study on the distribution of human papillomavirus (HPV) 16/18 in oral squamous cell carcinomas, leukoplakias and papillomas
• 발행기관: 대한구강악안면외과학회
• 저자명: 민우석(Woo Seok Min) 이의웅(Eui Wung Lee) 김진(Jin Kim)
• 간행물 정보: 『대한구강악안면외과학회지』대한구강악안면외과학회지 제19권 제4호, 477~487쪽, 전체 11쪽
• 주제분류: 의약학 > 내과학
• 파일형태: PDF
• 발행일자: 1993.10.30

영문 초록

There have been many reports on the etiological role of HPV in various oral diseases including carcinomas. Present study was performed to elucidate the distribution of HPV 16/18 in oral squamous cell carcinomas, leukoplakias and papillomas of Koreans. 24 cases of squamous cell carcinomas, 7 cases of leukoplakias and 6 cases of papillomas were reviewed through immunohistochemical staining using anti-HPV 16/18 E6 monoclonal antibody. Obtained results were as follows: 1. Positive reactions were observed in 6 cases out of 24 squamous cell carcinomas, Among the 6 positive cases 3 cases showed positive reaction both in the tumor cells and the adjacent epithelial cells, whereas the remaining 3 cases only in the adjacent epithelial cells. 2. 4 cases out of 7 leukoplakias reacted positively, all of which showed no dysplasia. 3. Positive stainings were observed in 4 cases out of 6 papillomas. These results confirm HPV involvement in oral papilloma, leukoplakia an squamous cell carcinoma, and support the hypothesis of HPV as an etiological agent in oral carcinogenesis. However, the frequency of positive reaction was much higher in benign lesions such as papillomas and leukoplakias, than in malignant lesions like squamous cell carcinomas. Therefore, HPV may be thought to be a co-factor in oral carcinogenesis together with chemical factor, rather than a single factor. And further studies will be needed to elucidate the role of HPV in oral carcinogenesis.

목차

Abstract

I. 서론

II. 연구대상 및 방법

III. 연구결과

IV. 총괄 및 고찰

V. 결론

VI. 참고문헌

키워드

lmmunohistochemical HPV 16/18 monoclonal antibody