冷凍 乾燥 및 脫灰 骨의 組織 反應에 關한 實驗的 硏究

• 영문명: An experimental study on tissue response of the freeze-dried and demineralized human bone
• 발행기관: 대한구강악안면외과학회
• 저자명: In Woong Um(嚴仁雄) Byong Il Min(閔丙一)
• 간행물 정보: 『대한구강악안면외과학회지』대한구강악안면외과학회지 제19권 제1호, 63~78쪽, 전체 16쪽
• 주제분류: 의약학 > 내과학
• 파일형태: PDF
• 발행일자: 1993.01.30

영문 초록

To evaluate the osteoinductive capacity of the bank bone procured from the oral and maxillofacial surgery patients, the histological and ultrastructural features of tissue response were studied after implantation of decalcified and undecalcified human bone which were partially decalcified in 0.5N HCl, approximately 1㎣ size with freeze-drying. The recipient site was chosen to a calvarial bone of the New Zealand white rabbit. Demineralized and undemineralized bone matrix showed different tissue response around the grafted matrix. After implantation of the demineralized bone matrix, there were no evidence of foreign body reaction and resorption, but were newly synthesized woven bone composed of irregular collagen fibers in early stage compared with the undemineralized bone matrix which showed osteoclast-like giant cells and reversal lines. At later stage of demineralized bone matrix, woven bone and scattered capillary formation have shown with a hematopoietic marrow and compact bone with the evidence of remodelling. Activities of collagen synthesis were not seen in typical osteoblasts but in fibroblastic or mesenchymal cells of the recipient sites. There were no significant differences of cellular activities between the demineralized and undemineralized bone groups in later stage.

목차

Abstract

I. 緖論

II. 硏究 材料 및 方法

III. 硏究 方法

III. 硏究 成績

IV. 總括 및 考案

V. 結論

REFERENCES

키워드

Allogeneic bone graft Demineralization Freeze-Drying Implantation New Bone Formation Resorption