가토 하악골 결손부의 골재생에 있어서 n-PTFE의 효과

• 영문명: THE EFFECT OF APPLICATION OF N-PTFE ON MANDIBULAR BONE DEFECTS OF RABBITS
• 발행기관: 대한구강악안면외과학회
• 저자명: 장도근(Do Geun Jang) 송재철(Jae Chul Song) 이용규(Yong Gyoo Lee) 김진수(Chin Soo Kim)
• 간행물 정보: 『대한구강악안면외과학회지』대한구강악안면외과학회지 제23권 제3호, 487~496쪽, 전체 10쪽
• 주제분류: 의약학 > 내과학
• 파일형태: PDF
• 발행일자: 1997.07.30

영문 초록

We observed the effect of application of n-PTFE on mandibular bone defects in the rabbit. GTR is based on the hypothesis that during wound healing, non-osteogenic cells are mechanically blocked from entering a bone defect. This allows the slower-migrating mesenchymal cells from the surrounding bone and marrow, having osteogenic potential, to move the defect site Bilateral through & through defects, 8mm * 4mm in size involving the inferior border of mandible, were created in the mandible angle of 15 rats. The experimental side was applied with high-density n-PTFE membrane, with the opposite side serving as a control. In the first week fo the early experimental period, the bone defects of experimental groups were filled with highly vascularized fibrous connective tissue showing prominent osteoblastic activity with osteoid formation, whereas the defects of control were replaced by dense fibro-muscular tissure without osteoblastic activity. After 3 weeks, the experimental group revealed well formed bone trabeculae and fibro-vascular marrow within surrounding membrane. membrane With time the amount of new bone was decreased with increase of hemato-poietic marrow, and the cortical plate composed of dense mature bone was more thicker. In the whole experimental periods, the inflammation and foreign body reaction were not found around the inserted n-PTFE membrane. In the whole experimental periods, the inflammation and foreign body reaction were not found around the inserted n-PTFE membrance. After remoival of membrane there was marked remodeling of newly formed bone by active osteoclasts in periosteal soft tissue, which decreased the bone volume apparantly. These findings suggest that n-PTFE has biocompatibility, flexibility, and rigidity and offer rapid bone regeneration within limited area by the membrane. On the other hand, the early removal of membrane caused reduction of bone volume by the osteoclastic resorption. Thus, the time of removal may be more important factor for maintenance of regenerated bone volume.

목차

Abstract

I. 서론

II. 재료 및 방법

III. 실험성적

IV. 고찰

V. 요약

참고문헌