Phthalate 3종에 대한 경피투과 특성 연구

• 영문명: Characteristics of Percutaneous Absorption for Three Kinds of Phthalate
• 발행기관: 한국환경보건학회
• 저자명: 정덕채(Duck-Chae Jung) 윤철훈(Cheol-HunYoon) 엄미선(Mi-SunUm) 황현석(Hyun-Suk Hwang) 백정훈(Jung-Hun Baek) 최진호(Jin-HoChoi)
• 간행물 정보: 『1. 한국환경보건학회지』제39권 제4호, 360~368쪽, 전체 9쪽
• 주제분류: 공학 > 환경공학
• 파일형태: PDF
• 발행일자: 2013.08.30

영문 초록

Objectives: Phthalates are used in a large variety of products including as coatings of pharmaceutical tablets, film formers, stabilizers, dispersants, emulsifying agents, and suspending agents. They have been the subject of great public concern in recent years. The extensive uses of this material have attracted attention and issues regarding its safety have been raised. Methods: In this study, three types of phthalate skin permeation were studied using matrixes such as ointments, creams and lotions in vitro. The absorption of phthalate diesters [Dimethyl phthalate (DMP), Din- propyl phthalate (DPP) and Di-n-pentyl phthalate (DNPP)] using film former has been measured in vitro through rat skin. Epidermal membranes were set up in Franz diffusion cells and their permeability to PBS measured in order to establish the integrity of the skin before the phthalates were applied to the epidermal surface. Results: Absorption rates for each phthalate ester were determined and permeability assessment made to quantify any irreversible alterations in barrier function due to contact with the esters. Types of phthalate in vitro experimental results quickly appeared in the following order DMP > DPP ≥ DNPP. Conclusions: In the experimental results, lotion> cream> ointment, and the permeation rate of lotion with a great amount of moisture was the fastest. Skin permeation rate is generally influenced by the chemical characteristics of a given chemical, such as molecular weight and lipophilicity. As the esters became more lipophilic and less hydrophilic, the rate of absorption decreased.

키워드

Phthalate skin permeation rate in vitro permeability Franz Cell