패혈증 의심환자에서 프로칼시토닌 검사의 효과

• 영문명: Effectiveness of procalcitonin test in patients with suspected sepsis : a systematic review
• 발행기관: 한국보건의료연구원
• 저자명: 조송희(Song hee Cho) 서재경(Jae Kyung Suh) 고민정(Min jeong Ko) 이상민(Sang min Lee) 장보형(Bo hyung Jang) 장은진(Eun Jin Jang)
• 간행물 정보: 『근거와 가치』제2권 제2호, 70~76쪽, 전체 7쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2016.06.30

영문 초록

Objectives: This study was to assess clinical effectiveness on determining discontinuation of antibiotics based on procalcitonin levels in sepsis suspected patients. Methods: Existing systematic review search was performed based on the pre-established strategy in various databases including EMBASE, Ovid-Medline, and KoreaMed. Prkno et al. (2013) was selected considering comprehensiveness of literature search, research scope, as well as the Assessment of Multiple Systematic Reviews (AMSTAR) score. Using the search strategy of the selected study, additional systematic search was conducted to identify randomized clinical trials (RCT) that compare the effectiveness of procalcitonin-based antibiotics therapy with standard care. In order to evaluate the quality of studies, the risk of bias assessment tool was used. All database search and quality assessment were conducted by two reviewers independently. Metaanalysis was performed using a random-effect model. Results: A total of 8 RCTs were included. Duration of antibiotic therapy was significantly reduced in procalcitonin-guided therapy group, compared to standard treatment group (mean difference, -2.43; 95% confidence interval, -3.46, -1.40), while 28-day mortality, hospital mortality, and length of stay did not show any significant difference. Conclusion: Procalcitonin-guided therapy shortened duration of antibiotic treatment compared to standard care without any harmful effect on other clinical outcomes such as mortality or length of hospital stay.

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키워드

Sepsis Procalcitonin-guided therapy Antibiotics discontinuation