학술논문
Radiotherapy and immune checkpoint blockades : a snapshot in 2016
이용수 10
- 영문명
- 발행기관
- 대한방사선종양학회
- 저자명
- Taeryool Koo In Ah Kim
- 간행물 정보
- 『대한방사선종양학회지』제34권 제4호, 250~259쪽, 전체 10쪽
- 주제분류
- 의약학 > 종양학
- 파일형태
- 발행일자
- 2016.12.30
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국문 초록
영문 초록
Immune checkpoint blockades including monoclonal antibodies (mAbs) of cytotoxic T-lymphocyte antigen-4 (CTLA-4), programmed death-1 (PD-1), and programmed death-ligand 1 (PD-L1) have been emerged as a promising anticancer therapy. Several immune checkpoint blockades have been approved by US Food and Drug Administration (FDA), and have shown notable success in clinical trials for patients with advanced melanoma and non-small cell lung cancer. Radiotherapy is a promising combination partner of immune checkpoint blockades due to its potent pro-immune effect. This review will cover the current issue and the future perspectives for combined with radiotherapy and immune checkpoint blockades based upon the available preclinical and clinical data.
목차
Abstract
Introduction
RT Combined with Checkpoint Blockades : Preclinical Data
RT Combined with Checkpoint Blockades : Clinical Data
How to Combine RT with Checkpoint Blockades?
Ongoing Trials and Future Perspectives
Conclusion
Conflict of Interest
Acknowledgments
References
키워드
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