구강악안면외과 영역의 전암병소 및 악성종양 치료를 위한 광역학 요법의 이용

• 영문명: PHOTODYNAMIC THERAPY OF PREMALIGNANT AND MALIGNANT LESIONS IN ORAL AND MAXILLOFACIAL SURGERY
• 발행기관: 대한구강악안면외과학회
• 저자명: 오정환 Alexander Kuebler Joachim E. Zoeller
• 간행물 정보: 『대한구강악안면외과학회지』대한구강악안면외과학회지 제28권 제3호, 234~238쪽, 전체 5쪽
• 주제분류: 의약학 > 내과학
• 파일형태: PDF
• 발행일자: 2002.06.30

영문 초록

Photodynamic therapy (PDT) is based on a photochemical reaction which is initiated by light activation of a photosensitizer. The photosensitizer accumulates more in tumor tissues than in normal tissues and is activated with specific wavelength of light, usually laser. The photochemical reaction produces highly reactive oxygen products causing cytotoxiciy and vascular shutdown to the tumor. The advantages of PDT are its relative selective tumor destruction and tissue healing by regeneration, which can maintain important structures with very good functional and esthetic results. Therefore, PDT is considered as an alternative modality for cancers of the head and neck. In this article, we will report three cases of photodynamic therapy for treatment of oral leukoplakia, squamous cell carcinoma, and basal cell carcinoma of head and neck. It was observed that premalignant and malignant lesions responded well to the photodynamic therapy with Aminolevulinic acid (ALA) and Foscan. Photodynamic therapy can be considered as a new treatment method for the premalignant and malignant tumors in Oral and Maxillofacial Surgery.

키워드

Photodynamic Therapy Photosensitizer Reactive Oxygen Products Cytotoxicity