치주인대 기원의 섬유아 세포에 압축력을 가한 경우 Interleukin-6 및 Interleukin-8의 발현 변화에 관한 연구

• 영문명: THE CHANGE OF EXPRESSION OF INTERLEUKIN-6 AND -8 AFTER THE APPLICATION OF THE STATIC COMPRESSIVE PRESSURE ON THE FIBROBLAST ORIGINATED FROM THE PERIODONTAL LIGAMENTS
• 발행기관: 대한구강악안면외과학회
• 저자명: 이연희(Yeon-Hee Lee) 김성곤(Seong-Gon Kim) 남동석(Dong-Seok Nahm)
• 간행물 정보: 『대한구강악안면외과학회지』대한구강악안면외과학회지 제32권 제5호, 426~429쪽, 전체 4쪽
• 주제분류: 의약학 > 내과학
• 파일형태: PDF
• 발행일자: 2006.10.30

영문 초록

The fibroblast in the periodontal ligaments received various stress. Among them, compression and tension are quite important and they are related to the remodeling of tooth and alveolar bone. We studied the change of expression of interleukin-6 (IL-6) and interleukin-8 (IL-8) in the fibroblasts of the periodontal ligaments by real-time RT-PCR and ELISA. In results, the relative activity of IL-6 mRNA in 2 hours after was 1.54±0.08 and 1.00±0.05 in control and test, respectively (P<0.05). Its 12 hours after was 1.23±0.06 and 2.78±0.14 in control and test, respectively (P<0.05). The relative activity of IL-8 mRNA in 2 hours after was 1.00±0.05 and 0.24±0.01 in control and test, respectively (P<0.05). Its 12 hours after was 1.23±0.06 and 0.63±0.03 in control and test, respectively (P<0.05). The concentration of IL-6 was 1.02±0.16 ng/ml, 0.90±0.14 ng/ml, and 1.32±0.12 ng/ml (P<0.05) in control, 2, and 12 hours after, respectively. The concentration of IL-8 was 2.26±0.17 ng/ml, 1.70±0.26 ng/ml (P<0.05), and 0.84±0.47 ng/ml (P<0.05) in control, 2, and 12 hours after, respectively. In conclusion, the expression of IL-6 was significantly increased after the application of the static compressive force, but IL-8 was significantly decreased. Considering their known function, their expression is quite important in tooth and bone resorption.

키워드

IL-6 IL-8 Compressive force