가토 두개골 결손 모델에서 Bioglass가 첨가된 불소화 수산화인회석의 골재생능력

• 영문명: Bone regeneration of the fluoridated hydroxyapatite and the bio-glass in the rabbit cranium defect model
• 발행기관: 대한구강악안면외과학회
• 저자명: 안효준(Hyo-Joon Ahn) 한세진(Se-Jin Han) 김경욱(Kyung-Wook Kim)
• 간행물 정보: 『대한구강악안면외과학회지』대한구강악안면외과학회지 제37권 제5호, 380~385쪽, 전체 6쪽
• 주제분류: 의약학 > 내과학
• 파일형태: PDF
• 발행일자: 2011.10.30

영문 초록

Introduction: Hydroxyapatite (Ca 10 (PO 4 ) 6 (OH) 2 , HA) is the main inorganic phase of human hard tissue that is used widely as the repair material for bones. When HA is applied to a bony defect, however, it can be encapsulated with fibrous tissue and float in the implanted area due to a lack of consolidation. Bioceramics as allogenic graft materials are added to HA to improve the rate and bone healing capacity. Fluoridated hydroxyapatite (Ca 10 (PO 4 ) 6 (OH,F) 2 , FHA), where F- partially replaces the OH- in hydroxyapatite, is considered a good alternative material for bone repair owing to its solubility and biocompatibility. Materials and Methods: This study was designed to determine the bone healing capacity of FHA newly produced as a nanoscale fiber in the laboratory. HA and FHA with bioglass was implanted in a rabbit cranium defect and the specimen was analysed histologically. Results: 1. At 4 weeks, fibrous connective tissue and little bone formation was observed around the materials of the experimental group I implanted HA and bioglass. Newly formed bone was observed around the materials in the experimental group II implanted FHA and bioglass. 2. At 8 weeks, the amount of newly formed and matured bone was higher in experimental group II than in experimental group I and the control group. Conclusion: These results suggest that FHA and bioglass is a relatively favorable bone substitute with biocompatibility and better bone healing capacity than pure HA and bioglass.

목차

Ⅰ. 서 론

Ⅱ. 연구 대상 및 방법

Ⅲ. 결 과

Ⅳ. 고 찰

키워드

Durapatite Fluor-hydroxylapatite Bioglass Bone Substitutes