스트렙토조토신으로 유도된 당뇨백서의 하악골 골절 치유에 관한 조직형태계측학적 연구

• 영문명: THE HISTOMORPHOMETRIC STUDY ON THE HEALING PROCESS OF A MANDIBULAR FRACTURE IN THE STREPTOZOTOCIN-INDUCED DIABETIC RATS
• 발행기관: 대한구강악안면외과학회
• 저자명: 강희제(Hee-Jea Kang) 김용덕(Yong-Deok Kim) 신상훈(Sang-Hun Shin) 김욱규(Uk-Kyu Kim) 김종렬(Jong-Ryoul Kim) 정인교(In-Kyo Chung)
• 간행물 정보: 『대한구강악안면외과학회지』대한구강악안면외과학회지 제32권 제3호, 250~261쪽, 전체 12쪽
• 주제분류: 의약학 > 내과학
• 파일형태: PDF
• 발행일자: 2006.06.30

영문 초록

Diabetes mellitus, as a major health problem for the elderly, is associated with an extensive list of complications involving nearly every tissue in the body and has been shown to alter the properties of bone and impair fracture healing in both human and animals. The objective of this study was to examine the healing process of a mandibular fracture in the streptozotocin-induced rats histomorphometrically and histologically. A standardized fracture model was chosen and based on blood-glucose value at the time of surgery. A total of 11-weeks old 36 rats were divided into 2 groups; One is a streptozotocin-induced diabetic group and the other is a non-diabetic group. All was fractured experimentally. Three animals from each group were killed 1, 2, 4, 6, 8 and 12 weeks after fracture and specimens were processed undecalcified for quantitative bone histomorphometric and histologic studies. The diabetic group showed a significant decrease of histomorphometry-based parameter including trabecular bone volume, trabecular thickness in comparison to the non-diabetic rat. This was confirmed histologically. In conclusion, this study suggests that in streptozotocin-induced diabetics, the healing process of bone fracture was impaired and delayed about 2-3 weeks comparing to non-diabetics.

키워드

DM Streptozotocin Fracture