Bisphosphonate-related osteonecrosis of the jaw의 병리조직학적 소견 및 방사선학적 특징에 대한 임상적 고찰

• 영문명: FEATURES OF HISTOPATHOLOGIC AND RADIOGRAPHIC FINDINGS IN BISPHOSPHONATE-RELATED OSTEONECROSIS OF JAW-CLINICAL REVIEW
• 발행기관: 대한구강악안면외과학회
• 저자명: 오주영(Joo-Young Ohe) 권용대(Yong-Dae Kwon) 김여갑(Yeo-Gab Kim) 이백수(Baek-Soo Lee) 윤병욱(Byoung-Wook Yoon) 최병준(Byoung-Jun Choi)
• 간행물 정보: 『대한구강악안면외과학회지』대한구강악안면회과학회지 제34권 제5호, 550~554쪽, 전체 5쪽
• 주제분류: 의약학 > 내과학
• 파일형태: PDF
• 발행일자: 2008.10.30

영문 초록

Bisphosphonates (BPs) are a class of agent used to treat patient with osteoporosis or malignant bone metastases. BPs can be categorized into 2 groups: nitrogen-containing and non-nitrogen containing. Nitrogen-containing BPs are considered to have more toxicity. Despite their clinical benefits, bisphosphonate-related osteonecrosis of jaw(BRONJ) is a significant complication to patients receveing these drugs. Since the first description of BRONJ in 2003 by Marx, the number of reports on BRONJ has been rapidly increasing. BRONJ is considered as an emerging problem in oral & maxillofacial surgery. Generally, osteonecrosis in the maxilla is rare, however BRONJ is found both in the maxilla and the mandible. This is an important feature of BRONJ compared to common infectious osteomyelitis of the jaw. Growing number of case reports, suggest that bisphosphonate therapy may cause exposed, necrotic bone. BRONJ has simillar features compared to IORN (infected osteoradionecrosis). BRONJ has meaningful features established through the interestigation on histopathologic and radiographic findings. These features have an impact on treatment plan and prognosis. This presentation contemplates on features of histopathologic and radiographic findings in bisphosphonate-related osteonecrosis of the jaw.

키워드

Bisphosphonate BRONJ Alendronate