측두하악관절 장애 환자에서 관절원판후조직의 에스트로겐 수용체(ER)의 단백 발현

• 영문명: EXPRESSION OF ESTROGEN RECEPTORS IN RETRODISCAL TISSUE OF THE TEMPOROMANDIBULAR JOINT DISORDER PATIENTS
• 발행기관: 대한구강악안면외과학회
• 저자명: 김종윤(Jong-Yun Kim) 임재형(Jae-Hyung Lim) 박광호(Kwang-Ho Park) 김형곤(Hyung-Gon Kim) 허종기(Jong-Ki Huh)
• 간행물 정보: 『대한구강악안면외과학회지』대한구강악안면회과학회지 제35권 제6호, 403~410쪽, 전체 8쪽
• 주제분류: 의약학 > 내과학
• 파일형태: PDF
• 발행일자: 2009.12.30

영문 초록

Those composing temporomandibular joint (TMJ) complex such as the temporal bone, the disc and the mandibular condyle perform their own functions with organic relation. The retrodiscal tissue is the main area of pain induction and contributes to compositional change of synovial fluid. If displacement of the disc lasts long time, not only adaptive changes, but also destructive or degenerative changes may happen. It was reported that these changes and symptoms appear mostly to female rather than male and especially, in the case of patients suffering from TMJ disorder, a large quantity of female sex hormone is found in the joint synovium. And that may play a role in bone resorption and inflammation. Also, the frequency and the intensity of pain perception for female is reported to be much more than for male. In this study, we investigated the expression extents of estrogen receptors (ER) and progesteron receptors (PR) in retrodiscal tissue with immunohistochemistry among the patients received TMJ surgery and compared with MRI findings and surgical findings. We report the relations between the expression of ER in retrodiscal tissue and the pathological change in TMJ, such as inflammation, internal derangement and osteoarthritis.

키워드

Sex hormones Estrogen receptors Temporomandibular joint Immunohistochemistry