비글견 경골에서 임플란트 식립 시 혈소판 농축 혈장이 골형성에 미치는 영향

• 영문명: The effect of platelet rich plasma in bone formation on implant installation in the tibia of beagle dogs
• 발행기관: 대한구강악안면외과학회
• 저자명: 국민석(Min-Suk Kook) 정승곤(Seunggon Jung) 심경미(Kyung-Mi Shim) 강성수(Seong-Soo Kang) 박홍주(Hong-Ju Park) 유선열(Sun-Youl Ryu) 오희균(Hee-Kyun Oh)
• 간행물 정보: 『대한구강악안면외과학회지』대한구강악안면회과학회지 제36권 제2호, 71~77쪽, 전체 7쪽
• 주제분류: 의약학 > 내과학
• 파일형태: PDF
• 발행일자: 2010.04.30

영문 초록

Introduction: The purpose of this study is to evaluate the effect of platelet rich plasma in bone formation and osseointegration of implant installed in the bone marrow space. Materials and Methods: Five beagle dogs were used as experimental animals. Two implants were installed on each tibia in the dogs. Implants of the control group were installed with no additional graft. Those of the experimental group 1 were installed with autogenous bone graft from the ilium autogenous bone. Platelet rich plasma (PRP) alone was used in experimental group 2 and the mixture of PRP and autogenous bone was used in experimental group 3. The animals were sacrificed at 8 weeks after implantation. The parts of tibia containing implant were harvested and radiographs were taken for radiographic examination. The specimens were prepared for histological examination and histomorphometric analysis of implant-bone contact ratios. Results: 1. All implants showed sufficient osseointegration in the cortical bone radiographically and histologically, but osseointergration in the marrow space was not satisfactory. 2. Histomorphometrically, the implant-bone contact ratios in the bone marrow was sequentially high in the experimental group 3 (autogenous bone+ PRP group), group 1 (autogenous bone group), group 2 (PRP group), and control group (non-additive). 3. It was verified that there was statistical significance between two experimental groups (group 1 and 3) and the other groups (group 2 and control group). (P<0.005) 4. However, there was no statistical significance between group 3 and group 1, also group 2 and control group respectively. Conclusion: These results suggest that platelet rich plasma is effective to osseointegration in the implant installation but there is no statistical significance.

키워드

Osseointegration Platelet rich plasma (PRP) Autogenous bone graft