Protective effect of rosemary on acrylamide motor neurotoxicity in spinal cord of rat offspring

• 발행기관: 대한해부학회
• 저자명: Marwa A. Al-Gholam Hanaa Zakaria Nooh Abeer E. El-Mehi Abd El-Moneum El-Barbary Ahmed Zo El Fokar
• 간행물 정보: 『Anatomy and Cell Biology』Vol.49(1), 34~49쪽, 전체 16쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2016.03.30

영문 초록

The direct interactive effects of rosemary and acrylamide on the development of motor neurons in the spinal cord remains unknown. Our goal is to confirm the protective effects of rosemary against motor neuronal degeneration induced by acrylamide in the developing postnatal rat spinal cord using a postnatal rat model. We assigned the offspring of treated female rats into control, rosemary; acrylamide group; and recovery groups. This work depended on clinical, histopathological, morphometrically, immunohistochemical and genetic methods. In the acrylamide group, we observed oxidation, motor neuron degeneration, apoptosis, myelin degeneration, neurofilament reduction, reactive gliosis. Whoever, concomitant rosemary intake and withdrawal of acrylamide modulate these effects. These findings proof that dietary rosemary can directly protect motor neuron against acrylamide toxicity in the mammalian developing spinal cord.

키워드

Acrylamide Motor neuron Rosemary Development Spinal cord