Lateral Lymph Node Metastasis Prediction in Papillary Thyroid Cancer Patients with Suspicious Preoperative Imaging Findings

• 영문명: Lateral Lymph Node Metastasis Prediction in Papillary Thyroid Cancer Patients with Suspicious Preoperative Imaging Findings
• 발행기관: 대한내분비외과학회
• 저자명: Han Shin Lee Eun Jung Jung Ju Yeon Kim Seung Jin Kwag Taejin Park1 Sang Ho Jeong Chi Young Jeong Young Tae Ju Young Joon Lee Soon Chan Hong Sang Kyung Choi Woo Song Ha
• 간행물 정보: 『The Koreran journal of Endocrine Surgery』16권1호, 6~12쪽, 전체 7쪽
• 주제분류: 의약학 > 일반외과학
• 파일형태: PDF
• 발행일자: 2016.03.31

영문 초록

Purpose: Lateral lymph node metastasis of papillary thyroid cancer (PTC) is indicative oftumor aggressiveness and can determine treatment strategies. However, the role ofprophylactic lateral lymph node dissection in the management of PTC is unclear. This studyevaluated factors predictive of lateral lymph node metastasis in patients with suspiciouslymph node enlargement in preoperative imaging.Methods: This retrospective study included 728 patients with newly diagnosed PTC whounderwent therapeutic surgery. Clinicopathologic results were reviewed, and factorspredictive of lateral lymph node metastasis were analyzed.Results: Of the 242 patients with lymph node metastasis, 50 had lateral lymph nodemetastasis. Lateral lymph node metastasis was associated with sex, tumor size, preoperativethyroid stimulating hormone (TSH) concentration and presence of central lymph nodemetastasis. Among patients with suspicious lateral lymph node metastasis by ultrasonography,high TSH level (odds ratio 3.833, P=0.031) and number of metastatic central lymphnodes (odds ratio 3.68, P=0.025) were significantly predictive of lateral lymph nodemetastasis.Conclusion: High serum TSH level and central lymph node metastasis were predictive oflateral lymph node metastasis in PTC patients with suspicious preoperative imagingfindings. These predictive factors might help reduce unnecessary therapeutic lateral lymphnode dissection.

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Abstract

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키워드

Papillary thyroid cancer Lateral lymph node metastasis TSH concentration Ultrasonography